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Stem Cell Biology and Regenerative Medicine
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  1. Home
  2. Programs
  3. Graduate
  4. Stem Cell Biology And Regenerative Medicine
  5. Doctor of Philosophy

Doctor of Philosophy

PhD
  • Stem Cell Bio Regenerative Medicine opens in a new tab
Program Minimum Units
135 Units
University Minimum Units
135 Units
Program Length
6 Years
Interests
Helping Others, Public Health, Technology, Experimentation & Discovery
Academic Areas
Health Sciences, Medicine

Overview

The Stanford Stem Cell Biology and Regenerative Medicine (SCBRM) program is dedicated to doctoral education that translates basic science to clinical applications, typically called Translational Science, and is of intense interest internationally in medical schools and universities. Our doctoral program provides exceptional didactic education and research experience in the basic sciences underlying stem cell biology. In addition, program participants will receive specialized training in developing and clinically applying discoveries in the basic sciences to achieve regenerative therapies. Thus, our graduates will be uniquely positioned to develop successful translational careers in Stem Cell Biology and Regenerative Medicine. They will emerge prepared to deliver on their passion for improving the human condition. The core curriculum combines unique research and clinical/professional immersion rotations to provide opportunities for doctoral students to specialize in the broad subject of translational medicine and yet focus specifically on the fundamentals of SCBRM. The curriculum combines genetics and developmental biology education with an introductory laboratory-based stem cell course, an advanced course in stem cell biology and regenerative medicine, and a clinical rotation with alternative law, business, and/or engineering opportunities.

Requirements

Program Requirements

Requirements Overview

Each student should complete three one-quarter laboratory rotations during their first year, with two one-quarter laboratory rotations being the minimum in special circumstances.

Students must perform two full quarter rotations in two different ISCBRM labs. Your first rotation (autumn quarter) must be with a member of the Institute of Stem Cell and Regenerative Medicine. If you are an ADVANCE student, your rotation in autumn quarter must be with a member of the Institute (even if you rotated with a member of the Institute in the summer).

All rotations outside of the Institute must be approved by the first-year faculty mentor or the Director of Graduate Studies via email prior to the start of the rotation.

At the end of their rotations, students will select a lab for thesis work with the signed approval of their first-year advisor. We encourage students to select a lab within the Institute, but it is possible to join labs that are outside the Institute. 

Joining a lab outside the Institute requires approval from the Faculty Executive Committee who will give permission based on mentorship record, area of study, and funding capacity of the chosen lab. To initiate this process, the student must submit a one page description stating why they want to join the particular out-of-Institute lab for the executive committee to review. 

The final deadline to choose a dissertation advisor is before the end of spring quarter of the first year.
 

SCBRM graduate students must be registered in all quarters. All required courses, including those counting toward the 10 units of elective credit, must be taken for a letter grade if offered and must be passed with a B grade or better. The course must be repeated if a student does not earn a B grade or better.

Complete all of the following requirements:
Core Courses
Complete all of the following course(s):
BIOS 200

Foundations in Experimental Biology

5 Units
DBIO 210

Developmental Biology

4 Units
MED 255

The Responsible Conduct of Research

1 Units
or
STEMREM 201B

Ethical Issues in Stem Cell Biology

1 Units
STEMREM 200

Stem Cell Intensive

1 Units
STEMREM 201A

Stem Cell Biology & Regenerative Medicine

1-3 Units
STEMREM 205

Bioinformatics for Stem Cell and Cancer Biology

3 Units
STEMREM 250

Regenerative Medicine Seminar Series

1 Units
STEMREM 280

Stem Cell Biology and Regenerative Medicine Journal Club

1 Units
STEMREM 399

Graduate Research

1-18 Units
and
Other Mandatory Courses

STEMREM 802 TGR (Register for 0 units each quarter once Terminal Graduate Registration (TGR) is achieved. TGR is achieved after completing 135 total units (spring quarter of year 4) and all required core coursework.)

Enroll in any of the following course(s):
STEMREM 802

TGR Dissertation

and
Electives

Complete a total of 10 units from Elective 1, Elective 2, and Elective 3 sections below.

Complete all of the following requirements:
Elective 1: Biochemistry Elective

Students must complete

Complete at least 1 and earn 3 - 4 units in the following course(s):
BIOC 241

Biological Macromolecules

3-5 Units
BIOE 331

Protein Engineering

3 Units
BIOE 361

Biomaterials in Regenerative Medicine

3 Units
BIOE 385

Biomaterials for Drug Delivery

3 Units
BIOS 204

Modeling Cell Signaling

3 Units
BIOS 294

Chemistry for Biologists and Others

3 Units
CSB 250

The Biology of Chromatin Templated Processes

3 Units
CSB 260

Concepts and Applications in Chemical Biology

3 Units
and
Elective 2: Advanced Genetics, Genomics, or Advanced Cell Biology
Complete at least 1 and earn 3 - 4 units in the following course(s):
BIO 214

Advanced Cell Biology

3 Units
GENE 205

Advanced Genetics

3 Units
GENE 211

Genomics

3 Units

and
Elective 3: Science Elective(s)
Complete at least 1 of the following courses:
BIO 152

Imaging: Biological Light Microscopy

3-5 Units
BIOE 374A

Biodesign Innovation: Needs Finding and Concept Creation

4 Units
BIOE 390

Introduction to Bioengineering Research

1-2 Units
BIOS 217

Foundations of statistics and reproducible research

2 Units
BIOS 224

Stem Cell Biology and Applications

2 Units
BIOS 227

Mass Spectrometry and Proteomics: Opening the Black Box

2 Units
BIOS 229

Open Source Prototyping: Translating Ideas to Reality using Rapid Prototyping Methods

1 Units
BIOS 268

Biology and Applications of CRISPR/Cas9: Genome Editing and Epigenome Modifications

1 Units
BIOS 272

Science and Art

1 Units
BIOS 296

Preparation & Practice: Biotechnology Business

1 Units
BIOS 319

Analysis of Public Companies in the Life Sciences

2 Units
BIOS 412

Antibody Anywhere All at Once: An Introduction to Techniques in Immunology

1 Units
BIOS 420

Building Connections, Defining the Future of Biosciences

1 Units
BMDS 210

Modeling Biomedical Systems

3 Units
CBIO 240

Molecular and Genetic Basis of Cancer

4 Units
COMPMED 210

Form and Funkiness of Lab Animals : Anatomy, Histology, and Pathology

4 Units
CS 106A

Programming Methodology

3-5 Units
CSB 243

Biotechnology and Development of Therapeutics

1-2 Units
CSB 245

Economics of Biotechnology

2 Units
ENGR 208

Patent Law and Strategy for Innovators and Entrepreneurs

2 Units
IMMUNOL 201

Advanced Immunology I

3 Units
MCP 256

How Cells Work: Energetics, Compartments, and Coupling in Cell Biology

4 Units
OTOHNS 204

Biology and Physics of Hearing

3 Units
STATS 195

Introduction to R

1 Units
STEMREM 223

Biology and Disease of Hematopoiesis

3 Units
STRAMGT 353

Entrepreneurship: Formation of New Ventures

4 Units
and
Grant Writing
Complete at least 1 of the following courses:
BIOS 242

Writing Compelling Fellowships and Career Development Awards

2 Units
BIOS 399

Write a Grant Proposal in 9 Weeks

2 Units
BIOS 425

Online Proposal Bootcamp

2 Units

  1. 135 units of coursework: including research, required courses, and approved electives.

  2. Maintain satisfactory degree progress with a significant physical presence on campus during the duration of the degree (GAP 3.1.1).

  3. Advance to Ph.D. candidacy through a University Oral Examination on proposed research (aka, “Qualifying Exam”) 

  4. Biochemistry proficiency is required by the end of the second year, as well as a total of 80 units and completed qualifying examinations. Students who do not pass the qualifying examination may retake a full qualifying exam, be retested in a few areas, or be asked to redo their presentation.

  5. Students must take advanced science elective units relevant to the dissertation and career goals, totaling at least ten units.

  6. All courses, including those counting toward the 10 science elective units, are taken for a letter grade when offered. Courses must be passed with a B or better; repeat the course if below a B is received.

  7. Present research at Stem Cell Club.

  8. Submit at least one first- or co-first-author peer-reviewed primary research manuscript to a journal (BioRxiv does not satisfy this requirement). Submission proof must be provided to the Student Services Officer and Director of Graduate Studies no later than the day the thesis is due.

  9. Perform a University Oral Examination on thesis research (aka, “Thesis Defense”). 

  10. Submit a written dissertation approved by the Dissertation Reading Committee.

MSTP Requirements

If you are in the Medical Scientist Training Program (MSTP) MD-PhD program pursuing a PhD in Stem Cell Biology and Regenerative Medicine, unlike your SCBRM PhD peers, you are NOT required to take:

  • BIOS 200 - Foundations in Experimental Biology 

  • DBIO 210 - Developmental Biology  

  • STEMREM 200 - Stem Cell Intensive  

  • 10 units of science electives toward the PhD

You are also not required to do 3 rotations since you will come to us already in a lab.

MSTP Required Courses for the SCBRM PhD

Core

Complete ALL of the following Courses:

  • MED 255 (Take in year two. Your PhD cohort will take it in year 1) or STEMREM 201b

  • STEMREM 201A - Stem Cell Biology & Regenerative Medicine 

  • STEMREM 205 - Bioinformatics for Stem Cell and Cancer Biology  

  • STEMREM 250 - Regenerative Medicine Seminar Series (ReMS)  (To be repeated 5 times. 5 units required.)

  • STEMREM 280 - SCBRM Journal Club  (To be repeated 5 times. 5 units required.)

  • STEMREM 399 - Graduate Research

Grant Writing 

Required Course

Complete one of the following courses:

  • BIOS 242 - Writing Compelling Fellowships and Career Development Awards

  • BIOS 299 - Online Proposal Bootcamp

  • BIOS 425 - Independent Study: Write a Grant Proposal in 9 Weeks

Advancement to Candidacy

Advancement to Candidacy

Prior to being formally admitted to candidacy for the PhD degree, the student must demonstrate knowledge of Stem Cell Biology and Regenerative Medicine fundamentals and a potential for research by passing a qualifying oral examination in their second year. 

The exam consists of an NIH-style written grant proposal and an oral examination. The Qualifying Exam Committee includes three faculty members but does not include the student’s thesis advisor. The examining committee includes the committee chair, who is an Academic Council member outside of ISCBRM and outside of the research mentor's department, and 2 ISCBRM faculty members (not including the research mentor) who are Academic Council members.

The written and oral proposal should represent the student’s efforts to identify a question of interest and to develop appropriate experimental approaches. The proposal must be submitted to committee members no later than ten days before the examination. The first page is a Specific Aims page, and other sections include Background-Significance and Research Plan (including a discussion of alternative approaches). The qualifying exam must be completed by the end of Autumn quarter of the second year and successful outcome is required to continue in the PhD program. If necessary, one retake will be permitted in the quarter following the first exam attempt.

Oral Exam

Oral Exam

A University Oral Examination is also required for the PhD degree. In the Stem Cell Biology and Regenerative Medicine Program, the PhD candidate presents a public seminar (one hour), followed by a closed-door oral examination. The University Oral Examination Committee consists of at least four examiners, including the student’s PI and a chair from an academic department outside of SCBRM, for a total of five people. All members of the Committee are usually members of the Academic Council, and the oral examination chair must be AC. With the prior approval of the ISCBRM Director, one of the examiners may be a person who is not a member of the Academic Council if that individual contributes expertise not readily available from the Stanford faculty. Official responsibility for selecting the oral examination committee rests with the student and their dissertation advisor.

Dissertation

Dissertation Overview

The major accomplishment of each successful PhD student is the presentation of a written dissertation resulting from an independent investigation that contributes to knowledge in Stem Cell Biology and Regenerative Medicine.

Annual Dissertation Committee Meetings

In year one, a dissertation committee meeting is not required. 

In year two, the qualifying exam is in place of the dissertation committee meeting.

In years three and four, each student must hold an annual dissertation committee meeting to assess progress toward the degree and for the committee to provide advice. 

In the fifth year and beyond, students are required to meet with their thesis committee twice a year.

Failure to meet with your dissertation committee within the required time frame will result in academic probation.

The Annual Dissertation Committee Meeting Form should be completed and signed by all committee members attending each meeting. The form should be returned to the SCBRM SSO. 

Dissertation TGR Course

Complete all of the following course(s):
STEMREM 802

TGR Dissertation